Jonas Brothers delivered a poignant moment during the ninth televised fundraising special Stand Up To Cancer with the performance of their brand-new song, “I Can’t Lose.”
The sibling trio, Nick, Joe, and Kevin Jonas, took the stage to share how cancer has impacted their family. “Our family was shocked when our father, Kevin Jonas senior, was diagnosed with colon cancer in 2017 after multiple procedures and treatments,” the group said collectively. “I’m happy to say that he has been in remission since 2018. The experience had an impact on all of us. It brought us closer, made us stronger as a family, and taught us the importance of early detection.”
Kevin Jonas went on to share how he was diagnosed with cancer last year. “So when I was diagnosed with a basal cell carcinoma in June of 2024, I was incredibly fortunate,” Kevin added. “Thanks to early detection in a great medical team, I had a successful procedure to remove the growth. So please make sure to get your moles checked.”
The Jonas Brothers then performed the heartfelt track, which they previously described as a tribute to “everyone affected by cancer.”
Jonas Brothers performance of “I Can’t Lose” struck a chord with viewers with their impressive harmonies and powerful lyrics.
“I can’t lose when I’m with you/ Oh-oh, you give me everything, everything that I need, everything that I need to keep smiling through-ooh-ooh/ I can’t lose when I’m with you/ Oh-oh, made out of magic and I gotta have it, I made it a habit to keep smiling through-ooh-ooh,” the Jonas Brothers sang in sync.
Co-written Nick Jonas, Mikky Ekko, Paris Carney and Ryan Daly, who also produced the track, “I Can’t Lose” appears on Jonas Brothers’ latest project, Greetings From Your Hometown. The song serves as the third single from the award-winning trio’s seventh studio album, which arrives on July 15, 2025.
“We debuted ‘I Can’t Lose’ – a song about love, strength, and showing up for the people you love. Dedicated to all of those who Stand Up To Cancer,” the sibling trio previously shared in a statement. “Teaming up with Mastercard to uplift fans who’ve found hope and healing in our music means so much to us. ‘I Can’t Lose’ is a song we hope can carry different meanings for everyone who hears it and, for those who need it, a reminder of their own strength.”
Jonas Brothers also joined forces with pop-country duo Dan + Shay to kick off the show with an epic cover of “Beautiful Day” by U2.
Hosted by GRAMMY Award-winning country superstar Sheryl Crow, the Stand Up To Cancer fundraising special also featured performances from Crow, Noah Cyrus, Gavin DeGraw, Marcus King, Brothers Osborne, Jon Pardi, Jelly Roll, Dan + Shay and CeCe Winans, joined by Nashville Community Gospel Choir.
The Stand Up To Cancer telecast, airing for the first time ever from The Pinnacle in Nashville, also included appearances from special guests such as Kevin Bacon, Jamie Foxx, Tim McGraw, Zoe Saldaña, Reese Witherspoon, Keith Urban, SU2C co-founder Katie Couric and more.
“Tonight was a powerful reminder of what’s possible when we come together with one shared goal, to end cancer,” Couric shared during the show. “We heard stories of hope, saw the progress that research is making right now, and felt the compassion and generosity of people from all walks of life. There’s still so much work ahead, but every donation, every action, brings us closer to a future where more people survive and thrive after a cancer diagnosis.”
Throughout the telecast, viewers also heard from top SU2C-funded researchers about recent breakthroughs and the importance of ongoing support in the fight against cancer. From early detection to innovative treatments, survivor stories showcased the real-world impact of SU2C’s work and the hope it brought to patients and families.
Donate today to help fund cancer research aimed at finding cures. Your contribution supports Stand Up To Cancer and its collaborative research programs. You can donate by calling 1-800-90-STAND or online by visiting StandUpToCancer.org.
For more information, visit StandUpToCancer.org, Instagram, TikTok, Twitter, Facebook, and YouTube.
